3-FPM, 3-FPH, PAL-593

Description

3-FPM, 3-FPH, PAL-593

3-Fluorophenmetrazine (also known as 3-FPM, 3-FPH and PAL-593) is a phenylmorpholine-based stimulant and fluorinated analogue of phenmetrazine

3-FPM acts as a norepinephrine-dopamine releasing agent with EC₅₀ values of 30 nM and 43 nM, respectively. It shows only negligible efficacy as a releaser of serotonin, with an EC₅₀ value of 2558 nM.

3-FPM also inhibits uptake mediated by dopamine transporters and norepinephrine transporters in HEK293 cells with potencies comparable to cocaine (IC50 values < 2.5 μM), but with less potent effects at serotonin transporters (IC50 values >80 μM).

At sufficient doses, 3-FPM is capable of reversing monoamine transporters, particularly transporters of the catecholamines dopamine and norepinephrine, and, to a much lesser degree, serotonin transporters, thereby releasing these neurotransmitters from the cytosol into the extracellular space, where they are active.

DISCOUNT:

10 – 24 – 20%

25 – 49 – 25%

50 – 99 – 30%

100 – 249 – 35%

250 – 499 – 40%

500 – 999 – 45%

1000 -9999 – 50%